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Viagra® is a short acting drug with an average half-life of 4–5 hours, which means that half the medicine is gone from the body after 4–5 hours in healthy people. The time that it takes to eliminate Viagra® may be prolonged in older people and people with liver or kidney disease and the drug may work longer in these people. It should be taken 30–60 minutes before sex, and it reaches peak blood levels in 60 minutes on average. Fat in a meal can delay the effects of Viagra® and also decrease the amount that is absorbed. Talk to your doctor about your medical conditions and your medications before taking Viagra®. Do not take Viagra® if you are allergic to its ingredients or if you are already taking nitrates , street drugs called “poppers” , or guanylate cyclase stimulators .

When VIAGRA 100 mg oral was co-administered with amlodipine, 5 mg or 10 mg oral, to hypertensive patients, the mean additional reduction on supine blood pressure was 8 mmHg systolic and 7 mmHg diastolic. In the third study, a single oral dose of VIAGRA 100 mg or matching placebo was administered in a 3-period crossover design to 20 generally healthy males with BPH. Treatment with doxazosin continued for at least 7 days after dose period 1. Hypersensitivity reactions have been reported, including rash and urticaria . In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for C max and 85% for AUC).

You may take VIAGRA between 30 minutes to 4 hours before sexual activity if needed. One-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-week, treatment-free run-in period. In healthy male volunteers, there was no evidence of a clinically significant effect of azithromycin on the systemic exposure of sildenafil or its major circulating metabolite. Sildenafil metabolism is principally mediated by CYP3A4 and CYP2C9 . Therefore, inhibitors of these isoenzymes may reduce sildenafil clearance and inducers of these isoenzymes may increase sildenafil clearance.

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In the meantime, no current evidence suggests that Viagra can enhance performance in baseball or any other sport. Nor is there any evidence to support the idea that Viagra and anabolic steroids, when taken together, enhance or accelerate steroid delivery. Be that as it may, history demonstrates that some athletes will continue to seek out new and different methods of performance enhancement, whether or not the science supports those methods. Viagra is not currently listed as a banned drug in sports, although eventually that may change.

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It is not a substitute for professional medical advice, diagnosis or treatment. Please seek the advice of a medical professional before making health care decisions. However, if Viagra is taken with a high-fat meal, it will take longer for its effects to work. Researchers analyzed randomized trials that had been published between January 2004 and May 2014, choosing 24 involving mixed populations of patients who were treated with PDE5i or a placebo. PDE5i was given to men who had cardiovascular disorders, but who did not necessarily suffer from sexual impotence, according to Isidori. Older men like Playboy’s Hugh Hefner and actor Michael Douglas have sung the praises of Viagra, but now scientists say the erectile dysfunction pill is not only good for your sex life — it’s good for your heart.

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It can be taken in a small dose daily or in a larger dose as needed. Vardenafil is effective for four to five hours or more if you have mild to moderate erectile dysfunction. A newer form of the drug that dissolves on the tongue might work faster than the pill that you swallow. This medication is most effective when taken on an empty stomach one hour before sex.

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At the same time, on-treatment function was better in treated patients who were less impaired at baseline. Sildenafil at steady state, at a dose not approved for the treatment of erectile dysfunction (80 mg t.i.d.) resulted in a 50% increase in AUC and a 42% increase in C max of bosentan (125 mg b.i.d.). In a study of healthy male volunteers, sildenafil did not affect the steady state pharmacokinetics of the HIV protease inhibitors, saquinavir and ritonavir, both of which are CYP3A4 substrates. Sildenafil is cleared predominantly by the CYP3A4 and CYP2C9 hepatic microsomal isoenzymes. The major circulating metabolite results from N-desmethylation of sildenafil, and is itself further metabolized. This metabolite has a PDE selectivity profile similar to sildenafil and an in vitro potency for PDE5 approximately 50% of the parent drug.

Talk to your doctor about eating grapefruit and drinking grapefruit juice while taking this medicine. Use the oral syringe provided with your medication to measure and take your dose. Do not mix the liquid with other medications or add anything to flavor the medication. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Do not take more or less of it or take it more often than prescribed by your doctor. According to a Pfizer study, around 80% of sites claiming to sell Viagra were selling counterfeits. Food and Drug Administration has approved fifteen drug manufacturers to market generic sildenafil in the United States.

  • VIAGRA did not potentiate the hypotensive effect of alcohol (0.5 g/kg) in healthy volunteers with mean maximum blood alcohol levels of 0.08%.
  • The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied.
  • According to a Pfizer study, around 80% of sites claiming to sell Viagra were selling counterfeits.
  • VIAGRA , an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate -specific phosphodiesterase type 5 .

If you are taking sildenafil for erectile dysfunction, your doctor will probably start you on an average dose of sildenafil and increase or decrease your dose depending on your response to the medication. Tell your doctor if sildenafil is not working well or if you are experiencing side effects. In 2000, Viagra sales accounted for 92% of the global market for prescribed erectile dysfunction pills. By 2007, Viagra’s global share had plunged to about 50% due to several factors, including the entry of Cialis and Levitra, along with several counterfeits and clones, and reports of vision loss in people taking PDE5 inhibitors. Acetildenafil and other synthetic structural analogs of sildenafil which are PDE5 inhibitors have been found as adulterants in a number of “herbal” aphrodisiac products sold over-the-counter.

Via­gra® can cre­ate adverse reac­tions in those that take cer­tain med­ica­tions or have cer­tain health con­di­tions, so be sure to tell your doc­tor all the med­ica­tions that you take and if you have any allergies. You should tell all your healthcare professionals that you take Viagra. If you need emergency medical care for a heart problem, it will be important for your healthcare professionals to know when you last took Viagra.